Pharmaceutical Granulation

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Pharmaceutical Granulation

Pharmaceutical Granulation

Product Description:
Pharmaceutical granulation is a process that turns fine powders into granules for use in tablets and capsules. It's a key step in the production of solid dosage forms.
How it works:
  • Mix the active pharmaceutical ingredient (API) and excipients in a defined ratio
  • Add a liquid or binder to form aggregates
  • Compact the powder using pressure
  • Dry the granules
  • Mill the granules to the desired size
Benefits:
Flowability: Granules flow better than powders, making them easier to fill and dose
Compressibility: Granules are easier to compress into tablets
Dust reduction: Granules produce less dust than powders, which reduces material loss and safety risks
Uniformity: Granules are more uniform than powders, which leads to more consistent tablet weight and strength
Types of granulation:
Wet granulation: Uses a liquid to form aggregates
Dry granulation: Uses pressure to compact the powder
Melt granulation: Uses a meltable binder that melts into the powder when heated
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